Generally speaking, the program can be used, however, some features are not compatible.

Incompatible Features

• Ramp/Curve setting for MIDI CC data (Cubase 11 / 12)

Moreover, there is currently a bug with the Mac version that causes some keyboard shortcuts to not work properly.

When using VOCALOID4.5 Editor for Cubase on a Mac with Apple silicon, please select the setting "Open using Rosetta" for Cubase.

Details on changing this setting can be found on the following support page from Apple.

https://support.apple.com/en-us/HT211861

Furthermore, no problems have been found with using the VOCALOID5 VST or VOCALOID5 AU versions with Cubase 10, Cubase 10.5, Cubase 11 or Cubase 12(Rosetta only), so we recommend that you use one of those.